Include any other markers that share with the arthritis diseases. Such as serum COMP are also found in rheumatic arthritis as well as OA. Urine CTXII does not. why?

Effect of molecular biomarkers and their pathogenesis in osteoarthritis.

Please include these in the research paper (Literature review)
1. The history of biomarkers in osteoarthritis.
2. A timeline of the biomarkers being discovered and the years (graphs/pictures to illustrate better).
3. Diagrams of biomarkers located and their types and tables
4. Diagram of the normal healthy cartilage of the knee and hip versus the cartilage of knee and hip osteoarthritis.
5. The types of molecular biomarkers – type 2 collagen cartilage, matrix metalloprotiease, enzyme, immunological, genetics, serum, urine, etc
6. Include any other markers that share with the arthritis diseases. Such as serum COMP are also found in rheumatic arthritis as well as OA. Urine CTXII does not. why?
5. Recent articles (less than 8 years) for the best cited molecular markers in osteoarthritis. (2012 onwards)

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