Compare the advantages and disadvantages of using animal models of Huntington’s disease (HD) for research.

Description

– Compare the advantages and disadvantages of using animal models (non-vertebrate models like drosophilla melanogaster, mice, primates, sheeps) of Huntington’s disease (HD) for research

– Outline difference between transgenic and knock-in mouse models of HD

– Describe behavioural test in animal models and relate them to symptoms of HD

– Compare and contrast arguments for HD inclusions (mutant huntington aggregates) being pathogenic and protective (if possible, put in some effects of mutant huntington protein)

– Describe the process of somatic expansion and understand the relevance of this to HD.

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