Discuss how adrenergic and muscarinic cholinergic receptor cascades can converge on specific ion channels to modulate their behavior.

Description

 

Using cardiac L-type Ca2+ channels as a focus

– Discuss the mechanisms that control and regulate protein phosphorylation and dephosphorylation at cardiac calcium channels (beta-adrenergic stimulation and L-type calcium channels) (citing experimental evidence of the calcium channel cascade which is the AKAP binding domain)

– Discuss how adrenergic and muscarinic cholinergic receptor cascades can converge on specific ion channels to modulate their behavior.

– Explain the physiological relevance of such post-translational ion channel modification

 

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