Explain how the most recent methods in transcriptomics (e.g. second generation sequencing) are relevant to annotate genomes and their interaction with the environment.

Genomics in molecular

Choose any two questions

1a. What is the evidence that the epigenome responds to environmental cues?
b. Describe with examples evidence that epigenetic memory exists in subsequent generations.
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2. Explain how the most recent methods in transcriptomics (e.g. second generation sequencing) are relevant to annotate genomes and their interaction with the environment.
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3. Compare and contrast Illumina NGS and standard targeted PCR approaches to the analysis of ancient DNA.
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4. Evaluate the strategies that used to find and confirm the identity of gene variants that are the cause of monogenic disorders.
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5. Discuss the evidence that genome wide association studies have been successful in identifying the gene variants that are responsible for polygenic disorders.

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