What is the biochemical rationale for the use of low dose aspirin in patients with coronary artery disease? Why is Ibuprofen not a good substituchote for aspirin in this case?

Eicosanoids
Based on the attached lecture write a clear biochemical response to the below questions. Do not exceed 2 pages for the responses. You may utilize Peer-reviewed Journal articles as supporting information to answer questions. Format of assignment is AMA. Include at least 3 citations:
A 65 year old retired construction worker is referred to the dialysis clinic following a recent diagnosis of chronic kidney disease due to a prolonged use of of the NSAID Ibuprofen. Explain the biochemical basis of NSAID nephropathy?
b. What is the biochemical rationale for the use of low dose aspirin in patients with coronary artery disease? Why is Ibuprofen not a good substituchote for aspirin in this case?

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