Demonstrate knowledge and understanding of the mechanisms underpinning the skeletal ion channelopathy disease process Discuss pathology and current and/or potential treatments Explain the experimental approaches and techniques used to research the disease processes. Evaluate recent progress made in research of developmental therapies, including limitations of current knowledge.
Description – Compare the advantages and disadvantages of using animal models (non-vertebrate models like drosophilla melanogaster, mice, primates, sheeps) of Huntington’s disease (HD) for research – Outline difference between transgenic and knock-in mouse models of HD – Describe behavioural test in animal models and relate them to symptoms of HD – Compare and contrast arguments […]
Description Using cardiac L-type Ca2+ channels as a focus – Discuss the mechanisms that control and regulate protein phosphorylation and dephosphorylation at cardiac calcium channels (beta-adrenergic stimulation and L-type calcium channels) (citing experimental evidence of the calcium channel cascade which is the AKAP binding domain) – Discuss how adrenergic and muscarinic cholinergic receptor cascades […]
Define the term channelopathy Explain how cardiac ion channelopathies can alter the action potential profile in cardiac cells and the electrical behaviour of the heart Discuss the physiology and pathophysiology of potassium ion channels in the heart, with particular focus on the impact of defective biophysical behaviour and/or altered trafficking of proteins to […]
Description – Understand how extracellular free ionised Ca2+ concentration is monitored, and the relative contributions of the parathyroid and kidney calcium-sensing receptor, CaSR – Discuss disorders of mineral ion metabolism due to alterations in CaSR expression and/or function – Discuss the discovery of positive allosteric modulators of the CaSR
In 2000 words, critically review the topic “sewage and other wastes as a biofuel source”.
Infection and Defects in Mechanisms of Defense 1. Describe the factors influencing infection by a pathogen — infectivity, virulence, pathogenicity, etc. 2. Define and differentiate antigenic drift from antigenic shift. 3. Compare bacterial, viral, and fungal infections, including manifestations 4. Explain how live, attenuated, and killed vaccines differ, as well as the relative risks and […]
Description Concerning Rash Your stepbrother John is 5 years old. One day he comes to the breakfast table with a bright red face almost as if he had been slapped. When you look more closely you can see thousands of tiny red bumps on his skin. He has a milder rash on his arms and […]
Description Fever and Sweats A 63-year-old international telecommunications executive visits your office with complaints of a high fever. The fever is not constant, but intermittent. When you press him for details he estimates that every three days or so he suffers these debilitating “sweats.” He usually has headaches and muscle aches during the episodes. They […]
Description Watery Diarrhea You are working as a receptionist at the only family practice in a small town in Idaho while you are studying to become a physician’s assistant. On a Saturday morning you are the only office worker there when a call comes in from a local church. The congregation is hosting a family […]
