Those parts of chemical space in which biologically active compounds reside. How do we best direct our efforts towards regions of chemical space that are most likely to contain molecules with useful biological activity?
Outline I Targets in Biology and Medicine II. Chemical Space III. Relevant Physicochemical Properties IV. Case Study V. Summary Targets in Biology and Medicine • Enzymes • Proteins • Nucleic acids • Channels • Membranes • Miscellaneous Knowledge discovery vs drug discovery • Ligand vs drug • Chemical tool to modulate each known protein • […]