Drug Y contains a carboxylic acid with a pKaof 4.3. When drug Y is added to a mixture of 1-octanol and water at pH 1.1, the concentration measured in 1-octanol is 230 μM and the concentration in water is 0.16 μM. What is the log P of drug Y?Discuss

Drug Y contains a carboxylic acid with a pKaof 4.3. When drug Y is added to a mixture of 1-octanol and water at pH 1.1, the concentration measured in 1-octanol is 230 μM and the concentration in water is 0.16 μM. What is the log P of drug Y?

A) -1.28

B) 0.83

C) 3.16

D) 3.86

E) 4.30