1. How did Edward Jenner test and create the first vaccine? Describe the steps of this process from observation to hypothesis to testing and finally, establishment of a theory.
(100 words or less) (The word count on all the short answer questions is a SUGGESTED word count. It is okay if you go over the word count. You will not lose points, but it easier for me to grade if you stay within the word count.)
2. Explain what is meant by viral host range. Also address what factors affect a virus’ host range, and what is meant by tissue tropism.
3. In your own words, describe the theory of endosymbiosis. (50 words or less).
4. Consider the following double-stranded DNA strands:
A)5′ ATG TTC ACA 3′
3′ TAC AAG TGT 5′
B)
5′ CCG GAG CTC 3′
3′ GGC CTC GAG 5′
Which DNA strand would require more energy to break the hydrogen bonds between itsbases? A or B? Why? (50 words or less).
5. Transcribe the DNA sequence seen below into its complementary RNA sequence:
GCA CCA TTG GCC ATG TGG ACC ACG GCA AGA
Then using the RNA sequence that you transcribed, please translate it into its corresponding amino acid sequence. Write the amino acid corresponding to each codon in the sequence. Use the amino acid chart to guide you.
6.Describe how DNA replication occurs on the leading strand vs. the lagging strand of DNA. Be sure to mention how are these processes similar? How are they different? (150 words or less).
7. Explain what is meant by the following diagram. (50 words or less). (You will need to view the exam on Canvas to see the diagram).
8. Describe the different ways that a bacteria can acquire drug resistance genes. (150 words or less)
9. Compare and contrast chickenpox and shingles. What is the name of the virus that causes these diseases? How are chickenpox and shingles similar? How are they different? How does chickenpox occur and how does shingles occur? Also explain why someone who once had chickenpox would require a shingles vaccine in older age.
(150
words or less)
10. What are the 3 means of horizontal gene transfer in bacteria? List them AND describe them. (Be sure to describe them! Not only mention them). (100 words or less).
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