Drug Y contains a carboxylic acid with a pKaof 4.3. When drug Y is added to a mixture of 1-octanol and water at pH 1.1, the concentration measured in 1-octanol is 230 μM and the concentration in water is 0.16 μM. What is the log P of drug Y?
A) -1.28
B) 0.83
C) 3.16
D) 3.86
E) 4.30
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