Find an example of an allosteric drug targeting some brain receptor that has been approved for the clinic (FDA-approved drug). Name this drug and describe its mechanism of action.

Format: Written response; minimum two pages of text (but not more than 2.5 pages). One page per question. Times new roman 12 pts. One-inch margins around; Single Line spacing.
Writing/response style: Try not just to list the information, don’t just rephrase the textbook; ***I am looking for your opinions. Whenever appropriate, argue as to why do you think a certain drug mechanism, drug effect, or drug properties are that way.** Use scientifically accurate terminology, not lay terms.

Allosteric modulators. (10 pts total)
a. Compare & contrast orthosteric (NOT orthostatic) and allosteric ligands (mechanism of action, possible functional outcomes of allosteric modulation, safety, etc.) (5)
b. Find an example of an allosteric drug targeting some brain receptor that has been approved for the clinic (FDA-approved drug). Name this drug and describe its mechanism of action. Cite this study. (5)

I’ve attached some studies/references about lorazepam for part b. Feel free to use these if easiest or choose another drug

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